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Clinical message: Oral GLP-1RA may become a practical intensification option before prandial insulin

Jang Won Son, Carel W le Roux, Matthias Blher, Michael A Nauck, Soo Lim Endocrine Reviews , First published online October 7, 2025, bnaf036 The approvals of semaglutide and tirzepatide have set new benchmarks in the treatment of type 2 diabetes and obesity

If that occurred, then -glutamyl cysteine, the final substrate of the glutathione synthase reaction (Figure 2, reaction 5), would be shunted into the dotted line pathway shown in Figure 2 instead of synthesis of glutathione